Effects of Cyclodextrins,Tween-80 and PVP on the Solubility and Dissolution Rate of Etoricoxib

Alone and combined effects of cyclodextrins (βCD and HPβCD), surfactant (Tween-80) and PVP on the solubility and dissolution rate of etoricoxib were evaluated in a series of 2 factorial design. The complexes of etoricoxib – CDs (βCD and HPβCD) were prepared with and without Tween-80 and PVP by kneading method as per 2 factorial designs. The solubility of etoricoxib in eight selected fluids containing CDs, Tween-80 and PVP was determined. The solubility of etoricoxib was markedly enhanced by βCD (2.24 fold), HPβCD (3.14 fold),Tween-80 (2.58 fold ) and PVP (1.38 fold) individually. βCD with PVP has given highest enhancement (3.44 fold). HPβCD with Tween 80 and PVP gave 3.74 and 3.39 fold increase in respectively. Alone and combined effects were highly significant (P<0.01). ANOVA indicated that the alone CDs (βCD and HPβCD),Tween-80 and PVP and their combined effects in enhancing the dissolution rate(K1) and DE30 were highly significant (P<0.01). βCD only gave a 1.18 fold increase in the dissolution rate. βCD with PVP and Tween-80 gave 3.0 and 7.4 fold increase in respectively . HPβCD only gave a 3.55 fold increase and in combination with PVP and Tween-80 it gave respectively 57.6 and 23.6 fold increase in the dissolution rate. Combination of CDs with either Tween-80 or PVP has markedly enhanced both the solubility and dissolution rate of etoricoxib.